Two sample MR report
RPS26_Endothelial Cell (Endo) against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 6 | 0.0026096 | 0.0365155 | 0.9464582 |
| Weighted median | 6 | -0.0427168 | 0.0123142 | 0.0005226 |
| Inverse variance weighted | 6 | -0.0505591 | 0.0095332 | 0.0000001 |
| Simple mode | 6 | -0.0423315 | 0.0179859 | 0.0652678 |
| Weighted mode | 6 | -0.0403128 | 0.0151022 | 0.0443837 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 1.725029 | 4 | 0.7861662 |
| Inverse variance weighted | 4.000210 | 5 | 0.5493858 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.028356 | 0.0187991 | 0.2059533 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0003983 | 0 | TRUE | 0.0598399 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
